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Once senescent cells are removed, the downstream benefits continue to develop as: SASP-driven inflammation progressively resolves Stem cell niches, previously suppressed by SASP factors, may reactivate Tissue remodeling and repair processes engage in cleared areas The paracrine senescence cascade (where SASP converts healthy cells to senescent ones) is interrupted In mouse models, improvements in kidney function and physical fitness persisted and in some cases continued to develop during the weeks following treatment cessation (Baar et al., 2017)

Reduces autoimmune diseases : The persistent oxidative stress often results in chronic autoimmune diseases such as rheumatoid arthritis

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This provides a middle ground between purely systemic and directly local administration

The protein expression of 4 Wnt and neurogenesis-related genes (FOXC1, NEURG2, SPRY1, and CTNNB1) in midbrain dopamine (DA) neurons is significantly reduced in rat models of PD

Oral supplements have also been shown to be effective at treating vitamin B12 deficiency